Cell atlas - CKS1B - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CKS1B
Gene description	CDC28 protein kinase regulatory subunit 1B
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & mitochondria. In addition localized to the nucleus & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved), Cytosol (approved)
Additional location	In addition localized to the Nucleus (approved), Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003424
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & mitochondria. In addition localized to the nucleus & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Mitochondria (approved), Cytosol (approved)

Additional location

Nucleus (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA003424	A549	Mitochondria	Intensity
HPA003424	A549	Cytosol	Intensity
HPA003424	PC-3	Nucleus	Intensity
		Vesicles	Intensity
		Cytosol
HPA003424	U-2 OS	Nucleus	Intensity
		Mitochondria	Intensity
		Cytosol	Intensity

GENE INFORMATION
Gene name	CKS1B (HGNC Symbol)
Synonyms	CKS1, ckshs1
Description	CDC28 protein kinase regulatory subunit 1B (HGNC Symbol)
Entrez gene summary	CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	154974653 - 154979249
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173207 (version 83.38)
Entrez gene	1163
UniProt	P61024 (UniProt - Evidence at protein level)
neXtProt	NX_P61024
Antibodypedia	CKS1B antibodies

PROTEIN BROWSER

CKS1B-001	CKS1B-002	CKS1B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CKS1B-001 ENSP00000311083 ENST00000308987	P61024 [Direct mapping] Cyclin-dependent kinases regulatory subunit 1 Q5T178 [Target identity:100%; Query identity:100%] Cyclin-dependent kinases regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0007049 [cell cycle] GO:0008283 [cell proliferation] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0051301 [cell division] Show all	79 aa 9.7 kDa	No	0
CKS1B-002 ENSP00000357424 ENST00000368439	Q9BZU3 [Direct mapping] Cyclin-dependent kinases regulatory subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007049 [cell cycle] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0045859 [regulation of protein kinase activity] GO:0051301 [cell division] Show all	63 aa 7.6 kDa	No	0
CKS1B-003 ENSP00000357421 ENST00000368436	Q5T179 [Direct mapping] Cyclin-dependent kinases regulatory subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007049 [cell cycle] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0045859 [regulation of protein kinase activity] GO:0051301 [cell division] Show all	67 aa 8 kDa	No	0