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CKS1B

GENERAL INFORMATION

Gene name

 CKS1B

Gene description

 CDC28 protein kinase regulatory subunit 1B

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA030762
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0510152025Tags Per Million

GENE INFORMATION

Gene name

 CKS1B (HGNC Symbol)

Synonyms

 CKS1, ckshs1

Description

 CDC28 protein kinase regulatory subunit 1B (HGNC Symbol)

Entrez gene summary

 CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 154974653 - 154979249

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173207 (version 83.38)

Entrez gene

 1163

UniProt

 P61024 (UniProt - Evidence at protein level)

neXtProt

 NX_P61024

Antibodypedia

 CKS1B antibodies

PROTEIN BROWSER
CKS1B-001
CKS1B-002
CKS1B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CKS1B-001
ENSP00000311083
ENST00000308987
P61024 [Direct mapping]
Cyclin-dependent kinases regulatory subunit 1
Q5T178 [Target identity:100%; Query identity:100%]
Cyclin-dependent kinases regulatory subunit
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0007049 [cell cycle]
GO:0008283 [cell proliferation]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0051301 [cell division]
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 79 aa
9.7 kDa 		No 0
CKS1B-002
ENSP00000357424
ENST00000368439
Q9BZU3 [Direct mapping]
Cyclin-dependent kinases regulatory subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007049 [cell cycle]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0045859 [regulation of protein kinase activity]
GO:0051301 [cell division]
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 63 aa
7.6 kDa 		No 0
CKS1B-003
ENSP00000357421
ENST00000368436
Q5T179 [Direct mapping]
Cyclin-dependent kinases regulatory subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007049 [cell cycle]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0045859 [regulation of protein kinase activity]
GO:0051301 [cell division]
Show all
 67 aa
8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.