Expression of VANGL1 in cancer - Summary

CANCER ATLAS

Gene description

VANGL planar cell polarity protein 1

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA025235

GENE INFORMATION
Gene name	VANGL1 (HGNC Symbol)
Synonyms	STB2
Description	VANGL planar cell polarity protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Chromosome	1
Cytoband	p13.1
Chromosome location (bp)	115641953 - 115698224
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173218 (version 83.38)
Entrez gene	81839
UniProt	Q8TAA9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAA9
Antibodypedia	VANGL1 antibodies

PROTEIN BROWSER

VANGL1-001	VANGL1-002	VANGL1-003	VANGL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VANGL1-001 ENSP00000358523 ENST00000369510	Q8TAA9 [Direct mapping] Vang-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] Show all	522 aa 59.7 kDa	No	4
VANGL1-002 ENSP00000358522 ENST00000369509	Q8TAA9 [Direct mapping] Vang-like protein 1 A0A024R0E3 [Target identity:100%; Query identity:100%] Vang-like 1 (Van gogh, Drosophila), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] Show all	524 aa 60 kDa	No	4
VANGL1-003 ENSP00000310800 ENST00000310260	Q8TAA9 [Direct mapping] Vang-like protein 1 A0A024R0E3 [Target identity:100%; Query identity:100%] Vang-like 1 (Van gogh, Drosophila), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] Show all	524 aa 60 kDa	No	4
VANGL1-201 ENSP00000347672 ENST00000355485	Q8TAA9 [Direct mapping] Vang-like protein 1 A0A024R0E3 [Target identity:100%; Query identity:100%] Vang-like 1 (Van gogh, Drosophila), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:0016328 [lateral plasma membrane] Show all	524 aa 60 kDa	No	4