Fields »
ABOUT
HELP
BLOG
VANGL1

GENERAL INFORMATION

Gene name

 VANGL1

Gene description

 VANGL planar cell polarity protein 1

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membranous cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA025235
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 VANGL1 (HGNC Symbol)

Synonyms

 STB2

Description

 VANGL planar cell polarity protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Chromosome

 1

Cytoband

 p13.1

Chromosome location (bp)

 115641953 - 115698224

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173218 (version 83.38)

Entrez gene

 81839

UniProt

 Q8TAA9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TAA9

Antibodypedia

 VANGL1 antibodies

PROTEIN BROWSER
VANGL1-001
VANGL1-002
VANGL1-003
VANGL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VANGL1-001
ENSP00000358523
ENST00000369510
Q8TAA9 [Direct mapping]
Vang-like protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007275 [multicellular organismal development]
GO:0016021 [integral component of membrane]
Show all
 522 aa
59.7 kDa 		No 4
VANGL1-002
ENSP00000358522
ENST00000369509
Q8TAA9 [Direct mapping]
Vang-like protein 1
A0A024R0E3 [Target identity:100%; Query identity:100%]
Vang-like 1 (Van gogh, Drosophila), isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007275 [multicellular organismal development]
GO:0016021 [integral component of membrane]
Show all
 524 aa
60 kDa 		No 4
VANGL1-003
ENSP00000310800
ENST00000310260
Q8TAA9 [Direct mapping]
Vang-like protein 1
A0A024R0E3 [Target identity:100%; Query identity:100%]
Vang-like 1 (Van gogh, Drosophila), isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007275 [multicellular organismal development]
GO:0016021 [integral component of membrane]
Show all
 524 aa
60 kDa 		No 4
VANGL1-201
ENSP00000347672
ENST00000355485
Q8TAA9 [Direct mapping]
Vang-like protein 1
A0A024R0E3 [Target identity:100%; Query identity:100%]
Vang-like 1 (Van gogh, Drosophila), isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007275 [multicellular organismal development]
GO:0016021 [integral component of membrane]
GO:0016328 [lateral plasma membrane]
Show all
 524 aa
60 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.