Cell atlas - ZNF449 - The Human Protein Atlas

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ZNF449

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZNF449
Gene description	Zinc finger protein 449
Protein class	Predicted intracellular proteins Predicted secreted proteins Transcription factors
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA018079
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018079	A-431	Nucleoplasm
	HPA018079	A-431	Cytosol
	HPA018079	U-2 OS	Aggresome
	HPA018079	U-251 MG	Nucleoplasm
	HPA018079	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ZNF449 (HGNC Symbol)
Synonyms	FLJ23614, ZSCAN19
Description	Zinc finger protein 449 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q26.3
Chromosome location (bp)	135344796 - 135363152
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173275 (version 83.38)
Entrez gene	203523
UniProt	Q6P9G9 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P9G9
Antibodypedia	ZNF449 antibodies

PROTEIN BROWSER

ZNF449-001	ZNF449-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF449-001 ENSP00000359797 ENST00000370761	Q6P9G9 [Direct mapping] Zinc finger protein 449 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	164 aa 19.2 kDa	No	0
ZNF449-002 ENSP00000339585 ENST00000339249	Q6P9G9 [Direct mapping] Zinc finger protein 449 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	518 aa 59.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.