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C1QA

GENERAL INFORMATION

Gene name

 C1QA

Gene description

 Complement component 1, q subcomponent, A chain

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in subsets of immune cells in several tissues, including spleen and lymph node. Distinct positivity in plasma.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA002350 , CAB009823
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 C1QA

Synonyms

Description

 Complement component 1, q subcomponent, A chain (HGNC Symbol)

Entrez gene summary

 This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 22636506 - 22639608

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173372 (version 83.38)

Entrez gene

 712

UniProt

 P02745 (UniProt - Evidence at protein level)

neXtProt

 NX_P02745

Antibodypedia

 C1QA antibodies

PROTEIN BROWSER
C1QA-001
C1QA-002
C1QA-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C1QA-001
ENSP00000363773
ENST00000374642
P02745 [Direct mapping]
Complement C1q subcomponent subunit A
A0A024RAG6 [Target identity:100%; Query identity:100%]
Complement component 1, q subcomponent, A chain, isoform CRA_a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005602 [complement component C1 complex]
GO:0006956 [complement activation]
GO:0006958 [complement activation, classical pathway]
GO:0007267 [cell-cell signaling]
GO:0010039 [response to iron ion]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
Show all
 245 aa
26 kDa 		Yes 0
C1QA-002
ENSP00000416841
ENST00000438241
X6RLJ0 [Direct mapping]
Complement C1q subcomponent subunit A
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
Show all
 221 aa
23.4 kDa 		Yes 0
C1QA-003
ENSP00000385564
ENST00000402322
P02745 [Direct mapping]
Complement C1q subcomponent subunit A
A0A024RAG6 [Target identity:100%; Query identity:100%]
Complement component 1, q subcomponent, A chain, isoform CRA_a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005602 [complement component C1 complex]
GO:0006956 [complement activation]
GO:0006958 [complement activation, classical pathway]
GO:0007267 [cell-cell signaling]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
Show all
 245 aa
26 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.