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Most malignant cells showed moderate nuclear and occasional cytoplasmic positivity. Most testicular cancers and several cases of urothelial, skin, endometrial, cervical and colorectal cancers displayed strong positivity. Renal cancers were negative.
Most testicular cancers displayed strong nuclear positivity. Skin cancers along with several malignant lymphomas, melanomas, urothelial and colorectal cancers showed moderate to strong nuclear immunoreactivity. Remaining malignant cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
SMARCC1 (HGNC Symbol)
Synonyms
BAF155, CRACC1, Rsc8, SRG3
Description
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001741 [XY body] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008286 [insulin receptor signaling pathway] GO:0009887 [organ morphogenesis] GO:0016514 [SWI/SNF complex] GO:0030850 [prostate gland development] GO:0031492 [nucleosomal DNA binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0090544 [BAF-type complex]
