Tissue expression of PTPRM - Summary - The Human Protein Atlas

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PTPRM

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PTPRM
Gene description	Protein tyrosine phosphatase, receptor type, M
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. CAB022442 , CAB022443
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

N/A

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PTPRM (HGNC Symbol)
Synonyms	hR-PTPu, PTPRL1, RPTPU
Description	Protein tyrosine phosphatase, receptor type, M (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	p11.23
Chromosome location (bp)	7566782 - 8406861
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173482 (version 83.38)
Entrez gene	5797
UniProt	P28827 (UniProt - Evidence at protein level)
neXtProt	NX_P28827
Antibodypedia	PTPRM antibodies

PROTEIN BROWSER

PTPRM-001	PTPRM-003	PTPRM-004	PTPRM-008	PTPRM-010	PTPRM-012	PTPRM-016	PTPRM-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPRM-001 ENSP00000331418 ENST00000332175	P28827 [Direct mapping] Receptor-type tyrosine-protein phosphatase mu Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001937 [negative regulation of endothelial cell proliferation] GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0006470 [protein dephosphorylation] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007165 [signal transduction] GO:0010596 [negative regulation of endothelial cell migration] GO:0010842 [retina layer formation] GO:0016020 [membrane] GO:0016311 [dephosphorylation] GO:0016525 [negative regulation of angiogenesis] GO:0016791 [phosphatase activity] GO:0030027 [lamellipodium] GO:0031175 [neuron projection development] GO:0031290 [retinal ganglion cell axon guidance] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0045296 [cadherin binding] GO:0048471 [perinuclear region of cytoplasm] Show all	1452 aa 163.7 kDa	Yes	1
PTPRM-003 ENSP00000382927 ENST00000400053	E7EPS8 [Direct mapping] Protein-tyrosine-phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	1390 aa 157.1 kDa	No	1
PTPRM-004 ENSP00000463558 ENST00000578916	J3QLI4 [Direct mapping] Receptor-type tyrosine-protein phosphatase mu Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	173 aa 18.7 kDa	No	0
PTPRM-008 ENSP00000462176 ENST00000583289	J3KRV2 [Direct mapping] Receptor-type tyrosine-protein phosphatase mu Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	264 aa 28.8 kDa	No	1
PTPRM-010 ENSP00000464128 ENST00000577468	J3QRB4 [Direct mapping] Receptor-type tyrosine-protein phosphatase mu Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	207 aa 23 kDa	No	1
PTPRM-012 ENSP00000463325 ENST00000580170	P28827 [Direct mapping] Receptor-type tyrosine-protein phosphatase mu Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001937 [negative regulation of endothelial cell proliferation] GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0006470 [protein dephosphorylation] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007165 [signal transduction] GO:0010596 [negative regulation of endothelial cell migration] GO:0010842 [retina layer formation] GO:0016020 [membrane] GO:0016311 [dephosphorylation] GO:0016525 [negative regulation of angiogenesis] GO:0016791 [phosphatase activity] GO:0030027 [lamellipodium] GO:0031175 [neuron projection development] GO:0031290 [retinal ganglion cell axon guidance] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0045296 [cadherin binding] GO:0045909 [positive regulation of vasodilation] GO:0048471 [perinuclear region of cytoplasm] Show all	1465 aa 165.1 kDa	Yes	1
PTPRM-016 ENSP00000462809 ENST00000583153	J3KT55 [Direct mapping] Receptor-type tyrosine-protein phosphatase mu Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	238 aa 26.5 kDa	No	0
PTPRM-201 ENSP00000382933 ENST00000400060	Q49AC9 [Direct mapping] PTPRM protein; Receptor-type tyrosine-protein phosphatase mu Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	279 aa 32.3 kDa	No	0

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The Human Protein Atlas

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