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The majority of cancers were either negative or displayed weak cytoplasmic immunoreactivity with additional nuclear staining in some cases. A few cases of stomach and renal cancers expressed moderate to strong staining. Red blood cells were distinctly stained.
GENE INFORMATION
Gene name
MST1 (HGNC Symbol)
Synonyms
D3F15S2, DNF15S2, HGFL, MSP, NF15S2
Description
Macrophage stimulating 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]