Cell atlas - MST1 - The Human Protein Atlas

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MST1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	MST1
Gene description	Macrophage stimulating 1
Protein class	Cancer-related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (Hep G2, U-266/70)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MST1 (HGNC Symbol)
Synonyms	D3F15S2, DNF15S2, HGFL, MSP, NF15S2
Description	Macrophage stimulating 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49683947 - 49689501
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173531 (version 83.38)
Entrez gene	4485
UniProt
neXtProt
Antibodypedia	MST1 antibodies

PROTEIN BROWSER

MST1-001	MST1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MST1-001 ENSP00000414287 ENST00000449682	G3XAK1 [Direct mapping] Hepatocyte growth factor-like protein; Macrophage stimulating 1 (Hepatocyte growth factor-like), isoform CRA_b Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005773 [vacuole] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0007566 [embryo implantation] GO:0010628 [positive regulation of gene expression] GO:0010758 [regulation of macrophage chemotaxis] GO:0030317 [sperm motility] GO:0030879 [mammary gland development] GO:0033601 [positive regulation of mammary gland epithelial cell proliferation] GO:0046425 [regulation of JAK-STAT cascade] GO:0060763 [mammary duct terminal end bud growth] GO:1904036 [negative regulation of epithelial cell apoptotic process] Show all	725 aa 82 kDa	Yes	0
MST1-015 ENSP00000394756 ENST00000448220	H7C0F8 [Direct mapping] Hepatocyte growth factor-like protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	195 aa 21 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.