Expression of TNFRSF10C in cancer - Summary

CANCER ATLAS

Gene description

Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain

Protein class

Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Lymphoma

STAINING SUMMARY

CAB025635

GENE INFORMATION
Gene name	TNFRSF10C (HGNC Symbol)
Synonyms	CD263, DcR1, LIT, TRAILR3, TRID
Description	Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	23084355 - 23117437
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173535 (version 83.38)
Entrez gene	8794
UniProt	O14798 (UniProt - Evidence at protein level)
neXtProt	NX_O14798
Antibodypedia	TNFRSF10C antibodies

PROTEIN BROWSER

TNFRSF10C-001	TNFRSF10C-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFRSF10C-001 ENSP00000349324 ENST00000356864	O14798 [Direct mapping] Tumor necrosis factor receptor superfamily member 10C Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0031225 [anchored component of membrane] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045569 [TRAIL binding] Show all	259 aa 27.4 kDa	Yes	1
TNFRSF10C-002 ENSP00000380815 ENST00000397703	E9PBT0 [Direct mapping] Tumor necrosis factor receptor superfamily member 10C Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Show all		155 aa 16.2 kDa	No	0