Tissue expression of TNFRSF10C - Summary - The Human Protein Atlas

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TNFRSF10C

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TNFRSF10C
Gene description	Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Protein class	Cancer-related genes CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (appendix)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Tissue enhanced (spleen, lymph node)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in subsets of immune cells in several tissues, including lymphoid tissues.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. CAB025635
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, lymph node)

GENE INFORMATION
Gene name	TNFRSF10C (HGNC Symbol)
Synonyms	CD263, DcR1, LIT, TRAILR3, TRID
Description	Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	23084355 - 23117437
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173535 (version 83.38)
Entrez gene	8794
UniProt	O14798 (UniProt - Evidence at protein level)
neXtProt	NX_O14798
Antibodypedia	TNFRSF10C antibodies

PROTEIN BROWSER

TNFRSF10C-001	TNFRSF10C-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFRSF10C-001 ENSP00000349324 ENST00000356864	O14798 [Direct mapping] Tumor necrosis factor receptor superfamily member 10C Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0031225 [anchored component of membrane] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045569 [TRAIL binding] Show all	259 aa 27.4 kDa	Yes	1
TNFRSF10C-002 ENSP00000380815 ENST00000397703	E9PBT0 [Direct mapping] Tumor necrosis factor receptor superfamily member 10C Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Show all		155 aa 16.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.