Expression of GMPPB in cancer - Summary

CANCER ATLAS

Gene description

GDP-mannose pyrophosphorylase B

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014657

GENE INFORMATION
Gene name	GMPPB (HGNC Symbol)
Synonyms	KIAA1851
Description	GDP-mannose pyrophosphorylase B (HGNC Symbol)
Entrez gene summary	This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49716844 - 49723951
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173540 (version 83.38)
Entrez gene	29925
UniProt	Q9Y5P6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5P6
Antibodypedia	GMPPB antibodies

PROTEIN BROWSER

GMPPB-001	GMPPB-002	GMPPB-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GMPPB-001 ENSP00000418565 ENST00000480687	Q9Y5P6 [Direct mapping] Mannose-1-phosphate guanyltransferase beta A0A024R2X1 [Target identity:100%; Query identity:100%] GDP-mannose pyrophosphorylase B, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004475 [mannose-1-phosphate guanylyltransferase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009058 [biosynthetic process] GO:0009298 [GDP-mannose biosynthetic process] GO:0016740 [transferase activity] GO:0016779 [nucleotidyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	360 aa 39.8 kDa	No	0
GMPPB-002 ENSP00000309092 ENST00000308375	Q9Y5P6 [Direct mapping] Mannose-1-phosphate guanyltransferase beta A0A024R329 [Target identity:100%; Query identity:100%] GDP-mannose pyrophosphorylase B, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004475 [mannose-1-phosphate guanylyltransferase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009058 [biosynthetic process] GO:0009298 [GDP-mannose biosynthetic process] GO:0016740 [transferase activity] GO:0016779 [nucleotidyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	387 aa 42.6 kDa	No	0
GMPPB-003 ENSP00000311130 ENST00000308388	Q9Y5P6 [Direct mapping] Mannose-1-phosphate guanyltransferase beta A0A024R2X1 [Target identity:100%; Query identity:100%] GDP-mannose pyrophosphorylase B, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004475 [mannose-1-phosphate guanylyltransferase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009058 [biosynthetic process] GO:0009298 [GDP-mannose biosynthetic process] GO:0016740 [transferase activity] GO:0016779 [nucleotidyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	360 aa 39.8 kDa	No	0