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GMPPB

GENERAL INFORMATION

Gene name

 GMPPB

Gene description

 GDP-mannose pyrophosphorylase B

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA014657
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GMPPB (HGNC Symbol)

Synonyms

 KIAA1851

Description

 GDP-mannose pyrophosphorylase B (HGNC Symbol)

Entrez gene summary

 This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 49716844 - 49723951

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173540 (version 83.38)

Entrez gene

 29925

UniProt

 Q9Y5P6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5P6

Antibodypedia

 GMPPB antibodies

PROTEIN BROWSER
GMPPB-001
GMPPB-002
GMPPB-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GMPPB-001
ENSP00000418565
ENST00000480687
Q9Y5P6 [Direct mapping]
Mannose-1-phosphate guanyltransferase beta
A0A024R2X1 [Target identity:100%; Query identity:100%]
GDP-mannose pyrophosphorylase B, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004475 [mannose-1-phosphate guanylyltransferase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 360 aa
39.8 kDa 		No 0
GMPPB-002
ENSP00000309092
ENST00000308375
Q9Y5P6 [Direct mapping]
Mannose-1-phosphate guanyltransferase beta
A0A024R329 [Target identity:100%; Query identity:100%]
GDP-mannose pyrophosphorylase B, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004475 [mannose-1-phosphate guanylyltransferase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 387 aa
42.6 kDa 		No 0
GMPPB-003
ENSP00000311130
ENST00000308388
Q9Y5P6 [Direct mapping]
Mannose-1-phosphate guanyltransferase beta
A0A024R2X1 [Target identity:100%; Query identity:100%]
GDP-mannose pyrophosphorylase B, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004475 [mannose-1-phosphate guanylyltransferase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 360 aa
39.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.