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PITPNA

GENERAL INFORMATION

Gene name

 PITPNA

Gene description

 Phosphatidylinositol transfer protein, alpha

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in squamous epithelia and subsets of stromal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA000528
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PITPNA (HGNC Symbol)

Synonyms

 PITPN, VIB1A

Description

 Phosphatidylinositol transfer protein, alpha (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 1517718 - 1562816

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174238 (version 83.38)

Entrez gene

 5306

UniProt

 Q00169 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00169

Antibodypedia

 PITPNA antibodies

PROTEIN BROWSER
PITPNA-001
PITPNA-003
PITPNA-004
PITPNA-005
PITPNA-006
PITPNA-007
PITPNA-008
PITPNA-009
PITPNA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PITPNA-001
ENSP00000316809
ENST00000313486
Q00169 [Direct mapping]
Phosphatidylinositol transfer protein alpha isoform
V9HWC5 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 36
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0007411 [axon guidance]
GO:0007601 [visual perception]
GO:0008289 [lipid binding]
GO:0008525 [phosphatidylcholine transporter activity]
GO:0008526 [phosphatidylinositol transporter activity]
GO:0015914 [phospholipid transport]
GO:0043209 [myelin sheath]
GO:0070062 [extracellular exosome]
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 270 aa
31.8 kDa 		No 0
PITPNA-003
ENSP00000461245
ENST00000574991
I3L4H1 [Direct mapping]
Phosphatidylinositol transfer protein alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 209 aa
24.6 kDa 		No 0
PITPNA-004
ENSP00000461539
ENST00000573056
I3L4U7 [Direct mapping]
Phosphatidylinositol transfer protein alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 121 aa
13.5 kDa 		No 0
PITPNA-005
ENSP00000461140
ENST00000575895
I3L4C0 [Direct mapping]
Phosphatidylinositol transfer protein alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 115 aa
13.3 kDa 		No 0
PITPNA-006
ENSP00000460771
ENST00000573231
I3L3W1 [Direct mapping]
Phosphatidylinositol transfer protein alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 44 aa
5.3 kDa 		No 0
PITPNA-007
ENSP00000461801
ENST00000576761
I3NI10 [Direct mapping]
Phosphatidylinositol transfer protein alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 66 aa
7.8 kDa 		No 0
PITPNA-008
ENSP00000460983
ENST00000576722
I3L459 [Direct mapping]
Phosphatidylinositol transfer protein alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 142 aa
16.7 kDa 		No 0
PITPNA-009
ENSP00000460008
ENST00000576010
I3L2X8 [Direct mapping]
Phosphatidylinositol transfer protein alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 83 aa
9.7 kDa 		No 0
PITPNA-201
ENSP00000441869
ENST00000539476
F5GWE5 [Direct mapping]
Phosphatidylinositol transfer protein alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 270 aa
31.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.