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GPR149

GENERAL INFORMATION

Gene name

 GPR149

Gene description

 G protein-coupled receptor 149

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (seminal vesicle)
GTEx:Group enriched (caudate, pituitary gland, hypothalamus)
FANTOM5:Group enriched (caudate, pituitary gland)

Protein evidence

 Evidence at transcript level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA018020
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (seminal vesicle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, pituitary gland, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, pituitary gland)

GENE INFORMATION

Gene name

 GPR149 (HGNC Symbol)

Synonyms

 IEDA, PGR10

Description

 G protein-coupled receptor 149 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q25.2

Chromosome location (bp)

 154337672 - 154429715

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000174948 (version 83.38)

Entrez gene

 344758

UniProt

 Q86SP6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86SP6

Antibodypedia

 GPR149 antibodies

PROTEIN BROWSER
GPR149-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPR149-001
ENSP00000374390
ENST00000389740
Q86SP6 [Direct mapping]
Probable G-protein coupled receptor 149
Q2MKA6 [Target identity:100%; Query identity:100%]
G protein-coupled receptor 149; HCG2022073
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
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GO:0001546 [preantral ovarian follicle growth]
GO:0001547 [antral ovarian follicle growth]
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0060280 [negative regulation of ovulation]
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 731 aa
81 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.