Expression of ZIC4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Zic family member 4

Protein class

Predicted intracellular proteins, Predicted secreted proteins, Transcription factors

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA030194

GENE INFORMATION
Gene name	ZIC4
Synonyms
Description	Zic family member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009]
Chromosome	3
Cytoband	q24
Chromosome location (bp)	147386046 - 147406860
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000174963 (version 83.38)
Entrez gene	84107
UniProt	Q8N9L1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N9L1
Antibodypedia	ZIC4 antibodies

PROTEIN BROWSER

ZIC4-001	ZIC4-002	ZIC4-003	ZIC4-004	ZIC4-009	ZIC4-010	ZIC4-011	ZIC4-201	ZIC4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZIC4-001 ENSP00000372553 ENST00000383075	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	334 aa 36.6 kDa	No	0
ZIC4-002 ENSP00000420627 ENST00000462748	C9JD04 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	229 aa 25.2 kDa	No	0
ZIC4-003 ENSP00000420775 ENST00000473123	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	334 aa 36.6 kDa	No	0
ZIC4-004 ENSP00000417855 ENST00000484399	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	334 aa 36.6 kDa	No	0
ZIC4-009 ENSP00000418277 ENST00000491672	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	128 aa 14.4 kDa	No	0
ZIC4-010 ENSP00000419727 ENST00000463250	C9JZU7 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Show all		68 aa 7.5 kDa	No	0
ZIC4-011 ENSP00000418343 ENST00000484586	C9J6T3 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Show all		77 aa 8.5 kDa	No	0
ZIC4-201 ENSP00000397695 ENST00000425731	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	372 aa 40.6 kDa	No	0
ZIC4-202 ENSP00000435509 ENST00000525172	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	384 aa 42.3 kDa	Yes	0