Tissue expression of ZIC4 - Summary - The Human Protein Atlas

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ZIC4

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ZIC4
Gene description	Zic family member 4
Protein class	Predicted intracellular proteins Predicted secreted proteins Transcription factors
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, skin)
GTEx:	Tissue enriched (cerebellum)
FANTOM5:	Tissue enriched (cerebellum)

Protein evidence

Evidence at transcript level

Protein expression

Nucleolar expression in several tissues.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA030194
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION
Gene name	ZIC4
Synonyms
Description	Zic family member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009]
Chromosome	3
Cytoband	q24
Chromosome location (bp)	147386046 - 147406860
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000174963 (version 83.38)
Entrez gene	84107
UniProt	Q8N9L1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N9L1
Antibodypedia	ZIC4 antibodies

PROTEIN BROWSER

ZIC4-001	ZIC4-002	ZIC4-003	ZIC4-004	ZIC4-009	ZIC4-010	ZIC4-011	ZIC4-201	ZIC4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZIC4-001 ENSP00000372553 ENST00000383075	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	334 aa 36.6 kDa	No	0
ZIC4-002 ENSP00000420627 ENST00000462748	C9JD04 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	229 aa 25.2 kDa	No	0
ZIC4-003 ENSP00000420775 ENST00000473123	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	334 aa 36.6 kDa	No	0
ZIC4-004 ENSP00000417855 ENST00000484399	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	334 aa 36.6 kDa	No	0
ZIC4-009 ENSP00000418277 ENST00000491672	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	128 aa 14.4 kDa	No	0
ZIC4-010 ENSP00000419727 ENST00000463250	C9JZU7 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Show all		68 aa 7.5 kDa	No	0
ZIC4-011 ENSP00000418343 ENST00000484586	C9J6T3 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Show all		77 aa 8.5 kDa	No	0
ZIC4-201 ENSP00000397695 ENST00000425731	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	372 aa 40.6 kDa	No	0
ZIC4-202 ENSP00000435509 ENST00000525172	Q8N9L1 [Direct mapping] Zinc finger protein ZIC 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	384 aa 42.3 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.