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Cancer tissues displayed moderate cytoplasmic immunoreactivity. Most endometrial cancers as well as few cases of gliomas, lymphomas, melanomas, prostate and colorectal cancers showed strong staining. Renal, hepatocellular and squamous cell carcinomas were in most cases weakly stained or negative.
GENE INFORMATION
Gene name
MARCKSL1 (HGNC Symbol)
Synonyms
F52, MacMARCKS, MLP, MLP1
Description
MARCKS-like 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]