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MARCKSL1

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GENERAL INFORMATION

Gene name

 MARCKSL1

Gene description

 MARCKS-like 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the actin filaments & nucleoplasm.

RNA cell category

 Cell line enhanced (AF22, NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Nucleoplasm (supported), Actin filaments (supported)

Mouse

 Localized to the Actin filaments, Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
CAB020787 , HPA030528
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the actin filaments & nucleoplasm.

Main location

 Cytosol (supported)

Additional location

 Nucleoplasm (supported), Actin filaments (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB020787 A-431 Nucleoplasm
Cytosol
CAB020787 U-2 OS Nucleoplasm
Cytosol
CAB020787 U-251 MG Nucleoplasm
Cytosol
HPA030528 HEK 293 Cytosol
HPA030528 Hep G2 Cytosol
HPA030528 U-2 OS Actin filaments
Cytosol

MOUSE CELLS

Main location

 Actin filaments, Cytosol

Additional location

 Nucleoli

Mouse gene

 ENSMUSG00000047945 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA030528 NIH 3T3 Nucleoli
Actin filaments
Cytosol

GENE INFORMATION

Gene name

 MARCKSL1 (HGNC Symbol)

Synonyms

 F52, MacMARCKS, MLP, MLP1

Description

 MARCKS-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

Chromosome

 1

Cytoband

 p35.1

Chromosome location (bp)

 32333832 - 32336379

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175130 (version 83.38)

Entrez gene

 65108

UniProt

 P49006 (UniProt - Evidence at protein level)

neXtProt

 NX_P49006

Antibodypedia

 MARCKSL1 antibodies

PROTEIN BROWSER
MARCKSL1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MARCKSL1-001
ENSP00000362638
ENST00000329421
P49006 [Direct mapping]
MARCKS-related protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008284 [positive regulation of cell proliferation]
GO:0070062 [extracellular exosome]
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 195 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.