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CKAP5

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GENERAL INFORMATION

Gene name

 CKAP5

Gene description

 Cytoskeleton associated protein 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (approved)

Additional location

 In addition localized to the Nucleoli (uncertain)

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA039377 , HPA040375
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleoli.

Main location

 Plasma membrane (approved), Cytosol (approved)

Additional location

 Nucleoli (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039377 A-431 Nucleoplasm
Plasma membrane
Cytosol
HPA039377 U-2 OS Cytosol
HPA039377 U-251 MG Cytosol
HPA040375 A-431 Nucleoli
Plasma membrane
Cytosol
HPA040375 U-2 OS Nucleoli
Plasma membrane
Cytosol
HPA040375 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 CKAP5 (HGNC Symbol)

Synonyms

 ch-TOG, KIAA0097, TOG, TOGp

Description

 Cytoskeleton associated protein 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 46743048 - 46846308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175216 (version 83.38)

Entrez gene

 9793

UniProt

 Q14008 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14008

Antibodypedia

 CKAP5 antibodies

PROTEIN BROWSER
CKAP5-001
CKAP5-002
CKAP5-003
CKAP5-006
CKAP5-009
CKAP5-010
CKAP5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CKAP5-001
ENSP00000434523
ENST00000525896
H0YDX5 [Direct mapping]
Cytoskeleton-associated protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 203 aa
22.6 kDa 		No 0
CKAP5-002
ENSP00000432768
ENST00000529230
Q14008 [Direct mapping]
Cytoskeleton-associated protein 5
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0000930 [gamma-tubulin complex]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007051 [spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0030951 [establishment or maintenance of microtubule cytoskeleton polarity]
GO:0035371 [microtubule plus-end]
GO:0043234 [protein complex]
GO:0050658 [RNA transport]
GO:0051297 [centrosome organization]
GO:0051301 [cell division]
Show all
 2032 aa
225.5 kDa 		No 0
CKAP5-003
ENSP00000346566
ENST00000354558
Q14008 [Direct mapping]
Cytoskeleton-associated protein 5
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0000930 [gamma-tubulin complex]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007051 [spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0030951 [establishment or maintenance of microtubule cytoskeleton polarity]
GO:0035371 [microtubule plus-end]
GO:0043234 [protein complex]
GO:0050658 [RNA transport]
GO:0051297 [centrosome organization]
GO:0051301 [cell division]
Show all
 1972 aa
218.5 kDa 		No 0
CKAP5-006
ENSP00000436769
ENST00000526496
E9PQH5 [Direct mapping]
Cytoskeleton-associated protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 151 aa
16.9 kDa 		No 0
CKAP5-009
ENSP00000436052
ENST00000526876
H0YEK7 [Direct mapping]
Cytoskeleton-associated protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 190 aa
21.7 kDa 		No 0
CKAP5-010
ENSP00000431509
ENST00000527333
H0YCF6 [Direct mapping]
Cytoskeleton-associated protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 167 aa
18.9 kDa 		No 0
CKAP5-201
ENSP00000310227
ENST00000312055
Q14008 [Direct mapping]
Cytoskeleton-associated protein 5
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0000930 [gamma-tubulin complex]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007051 [spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0030951 [establishment or maintenance of microtubule cytoskeleton polarity]
GO:0035371 [microtubule plus-end]
GO:0043234 [protein complex]
GO:0050658 [RNA transport]
GO:0051297 [centrosome organization]
GO:0051301 [cell division]
Show all
 1972 aa
218.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.