Expression of PHYKPL in cancer - Summary

CANCER ATLAS

Gene description

5-phosphohydroxy-L-lysine phospho-lyase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036461

GENE INFORMATION
Gene name	PHYKPL (HGNC Symbol)
Synonyms	AGXT2L2, MGC15875
Description	5-phosphohydroxy-L-lysine phospho-lyase (HGNC Symbol)
Entrez gene summary	This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	178208497 - 178232791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175309 (version 83.38)
Entrez gene	85007
UniProt	Q8IUZ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IUZ5
Antibodypedia	PHYKPL antibodies

PROTEIN BROWSER

PHYKPL-001	PHYKPL-010	PHYKPL-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHYKPL-001 ENSP00000310978 ENST00000308158	Q8IUZ5 [Direct mapping] 5-phosphohydroxy-L-lysine phospho-lyase Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006554 [lysine catabolic process] GO:0008483 [transaminase activity] GO:0016829 [lyase activity] GO:0022617 [extracellular matrix disassembly] GO:0030170 [pyridoxal phosphate binding] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] Show all	450 aa 49.7 kDa	No	0
PHYKPL-010 ENSP00000421810 ENST00000476170	D6RAR0 [Direct mapping] 5-phosphohydroxy-L-lysine phospho-lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] Show all	123 aa 13.9 kDa	No	0
PHYKPL-011 ENSP00000321290 ENST00000323594	H7BXR0 [Direct mapping] 5-phosphohydroxy-L-lysine phospho-lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] Show all	219 aa 24.7 kDa	No	0