Cell atlas - PHYKPL - The Human Protein Atlas

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PHYKPL

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	PHYKPL
Gene description	5-phosphohydroxy-L-lysine phospho-lyase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA063608
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063608	MCF7	No staining
	HPA063608	U-2 OS	Mitochondria	Intensity

GENE INFORMATION
Gene name	PHYKPL (HGNC Symbol)
Synonyms	AGXT2L2, MGC15875
Description	5-phosphohydroxy-L-lysine phospho-lyase (HGNC Symbol)
Entrez gene summary	This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	178208497 - 178232791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175309 (version 83.38)
Entrez gene	85007
UniProt	Q8IUZ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IUZ5
Antibodypedia	PHYKPL antibodies

PROTEIN BROWSER

PHYKPL-001	PHYKPL-010	PHYKPL-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHYKPL-001 ENSP00000310978 ENST00000308158	Q8IUZ5 [Direct mapping] 5-phosphohydroxy-L-lysine phospho-lyase Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006554 [lysine catabolic process] GO:0008483 [transaminase activity] GO:0016829 [lyase activity] GO:0022617 [extracellular matrix disassembly] GO:0030170 [pyridoxal phosphate binding] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] Show all	450 aa 49.7 kDa	No	0
PHYKPL-010 ENSP00000421810 ENST00000476170	D6RAR0 [Direct mapping] 5-phosphohydroxy-L-lysine phospho-lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] Show all	123 aa 13.9 kDa	No	0
PHYKPL-011 ENSP00000321290 ENST00000323594	H7BXR0 [Direct mapping] 5-phosphohydroxy-L-lysine phospho-lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] Show all	219 aa 24.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.