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PTPN2

CANCER ATLAS

Gene description

 Protein tyrosine phosphatase, non-receptor type 2

Protein class

 Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA015004
HPA046176

GENE INFORMATION

Gene name

 PTPN2 (HGNC Symbol)

Synonyms

 PTPT, TC-PTP, TCELLPTP, TCPTP

Description

 Protein tyrosine phosphatase, non-receptor type 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 12785478 - 12929643

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175354 (version 83.38)

Entrez gene

 5771

UniProt

 P17706 (UniProt - Evidence at protein level)

neXtProt

 NX_P17706

Antibodypedia

 PTPN2 antibodies

PROTEIN BROWSER
PTPN2-001
PTPN2-002
PTPN2-003
PTPN2-004
PTPN2-005
PTPN2-011
PTPN2-012
PTPN2-014
PTPN2-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTPN2-001
ENSP00000320546
ENST00000353319
P17706 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010888 [negative regulation of lipid storage]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019905 [syntaxin binding]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042512 [negative regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042527 [negative regulation of tyrosine phosphorylation of Stat6 protein]
GO:0042593 [glucose homeostasis]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0050922 [negative regulation of chemotaxis]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0060339 [negative regulation of type I interferon-mediated signaling pathway]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:1902202 [regulation of hepatocyte growth factor receptor signaling pathway]
GO:1902206 [negative regulation of interleukin-2-mediated signaling pathway]
GO:1902212 [negative regulation of prolactin signaling pathway]
GO:1902215 [negative regulation of interleukin-4-mediated signaling pathway]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1902233 [negative regulation of positive thymic T cell selection]
GO:2000587 [negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
Show all
 353 aa
41 kDa 		No 0
PTPN2-002
ENSP00000311857
ENST00000309660
P17706 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010888 [negative regulation of lipid storage]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019905 [syntaxin binding]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042512 [negative regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042527 [negative regulation of tyrosine phosphorylation of Stat6 protein]
GO:0042593 [glucose homeostasis]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0050922 [negative regulation of chemotaxis]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0060339 [negative regulation of type I interferon-mediated signaling pathway]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:1902202 [regulation of hepatocyte growth factor receptor signaling pathway]
GO:1902206 [negative regulation of interleukin-2-mediated signaling pathway]
GO:1902212 [negative regulation of prolactin signaling pathway]
GO:1902215 [negative regulation of interleukin-4-mediated signaling pathway]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1902233 [negative regulation of positive thymic T cell selection]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903899 [positive regulation of PERK-mediated unfolded protein response]
GO:2000587 [negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
Show all
 415 aa
48.5 kDa 		No 1
PTPN2-003
ENSP00000320298
ENST00000327283
P17706 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 2
A8K3N4 [Target identity:100%; Query identity:100%]
Tyrosine-protein phosphatase non-receptor type
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010888 [negative regulation of lipid storage]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019905 [syntaxin binding]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042512 [negative regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042527 [negative regulation of tyrosine phosphorylation of Stat6 protein]
GO:0042593 [glucose homeostasis]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0050922 [negative regulation of chemotaxis]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0060339 [negative regulation of type I interferon-mediated signaling pathway]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:1902202 [regulation of hepatocyte growth factor receptor signaling pathway]
GO:1902206 [negative regulation of interleukin-2-mediated signaling pathway]
GO:1902212 [negative regulation of prolactin signaling pathway]
GO:1902215 [negative regulation of interleukin-4-mediated signaling pathway]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1902233 [negative regulation of positive thymic T cell selection]
GO:2000587 [negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
Show all
 387 aa
45.2 kDa 		No 0
PTPN2-004
ENSP00000466936
ENST00000591115
P17706 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010888 [negative regulation of lipid storage]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019905 [syntaxin binding]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042512 [negative regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042527 [negative regulation of tyrosine phosphorylation of Stat6 protein]
GO:0042593 [glucose homeostasis]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0050922 [negative regulation of chemotaxis]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0060339 [negative regulation of type I interferon-mediated signaling pathway]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:1902202 [regulation of hepatocyte growth factor receptor signaling pathway]
GO:1902206 [negative regulation of interleukin-2-mediated signaling pathway]
GO:1902212 [negative regulation of prolactin signaling pathway]
GO:1902215 [negative regulation of interleukin-4-mediated signaling pathway]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1902233 [negative regulation of positive thymic T cell selection]
GO:2000587 [negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
Show all
 410 aa
48 kDa 		No 0
PTPN2-005
ENSP00000467823
ENST00000591497
K7EQG9 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 386 aa
44.6 kDa 		No 1
PTPN2-011
ENSP00000466206
ENST00000592059
K7ELS9 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 68 aa
8.1 kDa 		No 0
PTPN2-012
ENSP00000467043
ENST00000587703
K7ENP9 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 146 aa
17.1 kDa 		No 0
PTPN2-014
ENSP00000464719
ENST00000585666
K7EIE9 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 151 aa
17.6 kDa 		No 0
PTPN2-015
ENSP00000464937
ENST00000591901
K7EIY0 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 112 aa
13.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.