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Protein tyrosine phosphatase, non-receptor type 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
P17706 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 2
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Enzymes ENZYME proteins Hydrolases SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004725 [protein tyrosine phosphatase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005783 [endoplasmic reticulum] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005886 [plasma membrane] GO:0006470 [protein dephosphorylation] GO:0008285 [negative regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010888 [negative regulation of lipid storage] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019905 [syntaxin binding] GO:0030183 [B cell differentiation] GO:0030217 [T cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030971 [receptor tyrosine kinase binding] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042512 [negative regulation of tyrosine phosphorylation of Stat1 protein] GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein] GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein] GO:0042527 [negative regulation of tyrosine phosphorylation of Stat6 protein] GO:0042593 [glucose homeostasis] GO:0045650 [negative regulation of macrophage differentiation] GO:0045722 [positive regulation of gluconeogenesis] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0050728 [negative regulation of inflammatory response] GO:0050860 [negative regulation of T cell receptor signaling pathway] GO:0050922 [negative regulation of chemotaxis] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060339 [negative regulation of type I interferon-mediated signaling pathway] GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:1902202 [regulation of hepatocyte growth factor receptor signaling pathway] GO:1902206 [negative regulation of interleukin-2-mediated signaling pathway] GO:1902212 [negative regulation of prolactin signaling pathway] GO:1902215 [negative regulation of interleukin-4-mediated signaling pathway] GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway] GO:1902233 [negative regulation of positive thymic T cell selection] GO:2000587 [negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
