Expression of CLTB in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Clathrin, light chain B

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB003692

GENE INFORMATION
Gene name	CLTB (HGNC Symbol)
Synonyms	Lcb
Description	Clathrin, light chain B (HGNC Symbol)
Entrez gene summary	Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	176392455 - 176416569
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175416 (version 83.38)
Entrez gene	1212
UniProt	P09497 (UniProt - Evidence at protein level)
neXtProt	NX_P09497
Antibodypedia	CLTB antibodies

PROTEIN BROWSER

CLTB-001	CLTB-002	CLTB-005	CLTB-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLTB-001 ENSP00000309415 ENST00000310418	P09497 [Direct mapping] Clathrin light chain B Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030118 [clathrin coat] GO:0030125 [clathrin vesicle coat] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0032050 [clathrin heavy chain binding] GO:0042277 [peptide binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0060170 [ciliary membrane] GO:0072583 [clathrin-mediated endocytosis] Show all	229 aa 25.2 kDa	No	0
CLTB-002 ENSP00000310812 ENST00000345807	P09497 [Direct mapping] Clathrin light chain B A0A024R7S3 [Target identity:100%; Query identity:100%] Clathrin, light polypeptide (Lcb), isoform CRA_c Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030118 [clathrin coat] GO:0030125 [clathrin vesicle coat] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0032050 [clathrin heavy chain binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0072583 [clathrin-mediated endocytosis] Show all	211 aa 23.2 kDa	No	0
CLTB-005 ENSP00000427229 ENST00000502877	D6RJD1 [Direct mapping] Clathrin light chain B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030125 [clathrin vesicle coat] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0032050 [clathrin heavy chain binding] GO:0072583 [clathrin-mediated endocytosis] Show all	125 aa 13.1 kDa	No	0
CLTB-006 ENSP00000424739 ENST00000508425	H0Y9Q6 [Direct mapping] Clathrin light chain B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030125 [clathrin vesicle coat] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0032050 [clathrin heavy chain binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0072583 [clathrin-mediated endocytosis] Show all	81 aa 8.4 kDa	No	0