Cell atlas - CLTB - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CLTB
Gene description	Clathrin, light chain B
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Additional location	In addition localized to the Plasma membrane (approved), Cytosol (approved)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA036458
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the plasma membrane & cytosol.

Main location

Vesicles (supported)

Additional location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA036458	A-431	Vesicles
		Plasma membrane
		Cytosol
HPA036458	MCF7	Vesicles
HPA036458	MCF7	Cytosol
HPA036458	U-2 OS	Vesicles
HPA036458	U-2 OS	Plasma membrane

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000047547 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA036458	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	CLTB (HGNC Symbol)
Synonyms	Lcb
Description	Clathrin, light chain B (HGNC Symbol)
Entrez gene summary	Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	176392455 - 176416569
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175416 (version 83.38)
Entrez gene	1212
UniProt	P09497 (UniProt - Evidence at protein level)
neXtProt	NX_P09497
Antibodypedia	CLTB antibodies

PROTEIN BROWSER

CLTB-001	CLTB-002	CLTB-005	CLTB-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLTB-001 ENSP00000309415 ENST00000310418	P09497 [Direct mapping] Clathrin light chain B Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030118 [clathrin coat] GO:0030125 [clathrin vesicle coat] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0032050 [clathrin heavy chain binding] GO:0042277 [peptide binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0060170 [ciliary membrane] GO:0072583 [clathrin-mediated endocytosis] Show all	229 aa 25.2 kDa	No	0
CLTB-002 ENSP00000310812 ENST00000345807	P09497 [Direct mapping] Clathrin light chain B A0A024R7S3 [Target identity:100%; Query identity:100%] Clathrin, light polypeptide (Lcb), isoform CRA_c Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030118 [clathrin coat] GO:0030125 [clathrin vesicle coat] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0032050 [clathrin heavy chain binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0072583 [clathrin-mediated endocytosis] Show all	211 aa 23.2 kDa	No	0
CLTB-005 ENSP00000427229 ENST00000502877	D6RJD1 [Direct mapping] Clathrin light chain B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030125 [clathrin vesicle coat] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0032050 [clathrin heavy chain binding] GO:0072583 [clathrin-mediated endocytosis] Show all	125 aa 13.1 kDa	No	0
CLTB-006 ENSP00000424739 ENST00000508425	H0Y9Q6 [Direct mapping] Clathrin light chain B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030125 [clathrin vesicle coat] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0032050 [clathrin heavy chain binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0072583 [clathrin-mediated endocytosis] Show all	81 aa 8.4 kDa	No	0