Expression of PNLIP in cancer - Summary

CANCER ATLAS

Gene description

Pancreatic lipase

Protein class

Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA062430	HPA062494

GENE INFORMATION
Gene name	PNLIP (HGNC Symbol)
Synonyms	PL
Description	Pancreatic lipase (HGNC Symbol)
Entrez gene summary	This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q25.3
Chromosome location (bp)	116545931 - 116567855
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175535 (version 83.38)
Entrez gene	5406
UniProt	P16233 (UniProt - Evidence at protein level)
neXtProt	NX_P16233
Antibodypedia	PNLIP antibodies

PROTEIN BROWSER

PNLIP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNLIP-001 ENSP00000358223 ENST00000369221	P16233 [Direct mapping] Pancreatic triacylglycerol lipase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0004806 [triglyceride lipase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0007603 [phototransduction, visible light] GO:0016042 [lipid catabolic process] GO:0030299 [intestinal cholesterol absorption] GO:0044241 [lipid digestion] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0052689 [carboxylic ester hydrolase activity] GO:0061365 [positive regulation of triglyceride lipase activity] Show all	465 aa 51.2 kDa	Yes	0