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PNLIP

GENERAL INFORMATION

Gene name

 PNLIP

Gene description

 Pancreatic lipase

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (pancreas)
GTEx:Tissue enriched (pancreas)
FANTOM5:Tissue enriched (pancreas)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in pancreatic exocrine glandular cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA062430 , HPA062494
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)

GENE INFORMATION

Gene name

 PNLIP (HGNC Symbol)

Synonyms

 PL

Description

 Pancreatic lipase (HGNC Symbol)

Entrez gene summary

 This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q25.3

Chromosome location (bp)

 116545931 - 116567855

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175535 (version 83.38)

Entrez gene

 5406

UniProt

 P16233 (UniProt - Evidence at protein level)

neXtProt

 NX_P16233

Antibodypedia

 PNLIP antibodies

PROTEIN BROWSER
PNLIP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PNLIP-001
ENSP00000358223
ENST00000369221
P16233 [Direct mapping]
Pancreatic triacylglycerol lipase
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001523 [retinoid metabolic process]
GO:0004806 [triglyceride lipase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006629 [lipid metabolic process]
GO:0007603 [phototransduction, visible light]
GO:0016042 [lipid catabolic process]
GO:0030299 [intestinal cholesterol absorption]
GO:0044241 [lipid digestion]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0061365 [positive regulation of triglyceride lipase activity]
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 465 aa
51.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.