Cell atlas - KCNE3 - The Human Protein Atlas

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KCNE3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	KCNE3
Gene description	Potassium channel, voltage gated subfamily E regulatory beta subunit 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HEL, NB-4, THP-1, EFO-21, CACO-2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, NB-4, THP-1, EFO-21, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	KCNE3 (HGNC Symbol)
Synonyms	HOKPP, MiRP2
Description	Potassium channel, voltage gated subfamily E regulatory beta subunit 3 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	74454841 - 74467729
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175538 (version 83.38)
Entrez gene	10008
UniProt	Q9Y6H6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6H6
Antibodypedia	KCNE3 antibodies

PROTEIN BROWSER

KCNE3-001	KCNE3-003	KCNE3-005	KCNE3-006	KCNE3-007	KCNE3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNE3-001 ENSP00000310557 ENST00000310128	Q9Y6H6 [Direct mapping] Potassium voltage-gated channel subfamily E member 3 Q6IAE6 [Target identity:100%; Query identity:100%] KCNE3 protein; Potassium voltage-gated channel subfamily E member 3; Potassium voltage-gated channel, Isk-related family, member 3; Putative uncharacterized protein DKFZp781H21101; cDNA, FLJ92142, Homo sapiens potassium voltage-gated channel, Isk-related family,member 3 (KCNE3), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0030425 [dendrite] GO:0032809 [neuronal cell body membrane] GO:0043204 [perikaryon] GO:0043266 [regulation of potassium ion transport] GO:0044325 [ion channel binding] GO:0060306 [regulation of membrane repolarization] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] GO:1901387 [positive regulation of voltage-gated calcium channel activity] GO:1902260 [negative regulation of delayed rectifier potassium channel activity] GO:1903817 [negative regulation of voltage-gated potassium channel activity] Show all	103 aa 11.7 kDa	No	1
KCNE3-003 ENSP00000433633 ENST00000525550	Q9Y6H6 [Direct mapping] Potassium voltage-gated channel subfamily E member 3 Q6IAE6 [Target identity:100%; Query identity:100%] KCNE3 protein; Potassium voltage-gated channel subfamily E member 3; Potassium voltage-gated channel, Isk-related family, member 3; Putative uncharacterized protein DKFZp781H21101; cDNA, FLJ92142, Homo sapiens potassium voltage-gated channel, Isk-related family,member 3 (KCNE3), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0005737 [cytoplasm] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0030425 [dendrite] GO:0032809 [neuronal cell body membrane] GO:0043204 [perikaryon] GO:0060306 [regulation of membrane repolarization] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] GO:1902260 [negative regulation of delayed rectifier potassium channel activity] Show all	103 aa 11.7 kDa	No	1
KCNE3-005 ENSP00000431739 ENST00000532569	Q2N1I1 [Direct mapping] Cardiac voltage-gated potassium channel accessory subunit isoform 3a; Cardiac voltage-gated potassium channel accessory subunit isoform 3b; Potassium voltage-gated channel subfamily E member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0060306 [regulation of membrane repolarization] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	99 aa 11.3 kDa	No	1
KCNE3-006 ENSP00000434890 ENST00000529425	E9PN03 [Direct mapping] Potassium voltage-gated channel subfamily E member 3 Show all	Predicted intracellular proteins Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0060306 [regulation of membrane repolarization] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	50 aa 5.5 kDa	No	0
KCNE3-007 ENSP00000435539 ENST00000526855	E9PJQ7 [Direct mapping] Potassium voltage-gated channel subfamily E member 3 Show all	Predicted intracellular proteins Show all	GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0060306 [regulation of membrane repolarization] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	12 aa 1.5 kDa	No	0
KCNE3-008 ENSP00000433697 ENST00000531854	E9PJV9 [Direct mapping] Potassium voltage-gated channel subfamily E member 3 Show all	Predicted intracellular proteins Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0060306 [regulation of membrane repolarization] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	53 aa 5.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.