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Most cases of melanoma, glioma, ovarian, thyroid, renal and hepatic cancers displayed moderate to strong staining. Remaining cancer cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
KCNE3 (HGNC Symbol)
Synonyms
HOKPP, MiRP2
Description
Potassium channel, voltage gated subfamily E regulatory beta subunit 3 (HGNC Symbol)
Entrez gene summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]