Expression of RPS6KB2 in cancer - Summary

CANCER ATLAS

Gene description

Ribosomal protein S6 kinase, 70kDa, polypeptide 2

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA010010	CAB019404

GENE INFORMATION
Gene name	RPS6KB2 (HGNC Symbol)
Synonyms	KLS, P70-BETA, p70S6Kb, STK14B
Description	Ribosomal protein S6 kinase, 70kDa, polypeptide 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	67428460 - 67435408
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175634 (version 83.38)
Entrez gene	6199
UniProt	Q9UBS0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBS0
Antibodypedia	RPS6KB2 antibodies

PROTEIN BROWSER

RPS6KB2-003	RPS6KB2-006	RPS6KB2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPS6KB2-003 ENSP00000308413 ENST00000312629	Q9UBS0 [Direct mapping] Ribosomal protein S6 kinase beta-2 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004711 [ribosomal protein S6 kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006412 [translation] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042277 [peptide binding] GO:0043491 [protein kinase B signaling] GO:0045087 [innate immune response] GO:0045948 [positive regulation of translational initiation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] Show all	482 aa 53.5 kDa	No	0
RPS6KB2-006 ENSP00000436811 ENST00000524934	E9PQF6 [Direct mapping] Ribosomal protein S6 kinase beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004711 [ribosomal protein S6 kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] Show all	138 aa 15 kDa	No	0
RPS6KB2-009 ENSP00000410175 ENST00000420069	E9PIP7 [Direct mapping] Ribosomal protein S6 kinase beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004711 [ribosomal protein S6 kinase activity] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] Show all	20 aa 2.2 kDa	No	0