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RPS6KB2

GENERAL INFORMATION

Gene name

 RPS6KB2

Gene description

 Ribosomal protein S6 kinase, 70kDa, polypeptide 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in all tissues at variable levels.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA010010 , CAB019404
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RPS6KB2 (HGNC Symbol)

Synonyms

 KLS, P70-BETA, p70S6Kb, STK14B

Description

 Ribosomal protein S6 kinase, 70kDa, polypeptide 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 67428460 - 67435408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175634 (version 83.38)

Entrez gene

 6199

UniProt

 Q9UBS0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBS0

Antibodypedia

 RPS6KB2 antibodies

PROTEIN BROWSER
RPS6KB2-003
RPS6KB2-006
RPS6KB2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS6KB2-003
ENSP00000308413
ENST00000312629
Q9UBS0 [Direct mapping]
Ribosomal protein S6 kinase beta-2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006412 [translation]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042277 [peptide binding]
GO:0043491 [protein kinase B signaling]
GO:0045087 [innate immune response]
GO:0045948 [positive regulation of translational initiation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
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 482 aa
53.5 kDa 		No 0
RPS6KB2-006
ENSP00000436811
ENST00000524934
E9PQF6 [Direct mapping]
Ribosomal protein S6 kinase beta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
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 138 aa
15 kDa 		No 0
RPS6KB2-009
ENSP00000410175
ENST00000420069
E9PIP7 [Direct mapping]
Ribosomal protein S6 kinase beta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
Show all
 20 aa
2.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.