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MSRA

GENERAL INFORMATION

Gene name

 MSRA

Gene description

 Methionine sulfoxide reductase A

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Tissue enriched (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA023804
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION

Gene name

 MSRA

Synonyms

Description

 Methionine sulfoxide reductase A (HGNC Symbol)

Entrez gene summary

 This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 10054268 - 10428891

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175806 (version 83.38)

Entrez gene

 4482

UniProt

 Q9UJ68 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJ68

Antibodypedia

 MSRA antibodies

PROTEIN BROWSER
MSRA-001
MSRA-002
MSRA-003
MSRA-004
MSRA-005
MSRA-006
MSRA-008
MSRA-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MSRA-001
ENSP00000313921
ENST00000317173
Q9UJ68 [Direct mapping]
Mitochondrial peptide methionine sulfoxide reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006464 [cellular protein modification process]
GO:0006555 [methionine metabolic process]
GO:0006979 [response to oxidative stress]
GO:0008113 [peptide-methionine (S)-S-oxide reductase activity]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030091 [protein repair]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 235 aa
26.1 kDa 		Yes 0
MSRA-002
ENSP00000435644
ENST00000521209
E9PJ70 [Direct mapping]
Mitochondrial peptide methionine sulfoxide reductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006979 [response to oxidative stress]
GO:0008113 [peptide-methionine (S)-S-oxide reductase activity]
GO:0030091 [protein repair]
GO:0055114 [oxidation-reduction process]
Show all
 59 aa
6.6 kDa 		No 0
MSRA-003
ENSP00000410912
ENST00000441698
Q9UJ68 [Direct mapping]
Mitochondrial peptide methionine sulfoxide reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006464 [cellular protein modification process]
GO:0006555 [methionine metabolic process]
GO:0006979 [response to oxidative stress]
GO:0008113 [peptide-methionine (S)-S-oxide reductase activity]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030091 [protein repair]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 195 aa
21.7 kDa 		Yes 0
MSRA-004
ENSP00000428214
ENST00000522907
E5RJK1 [Direct mapping]
Mitochondrial peptide methionine sulfoxide reductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006979 [response to oxidative stress]
GO:0008113 [peptide-methionine (S)-S-oxide reductase activity]
GO:0030091 [protein repair]
GO:0055114 [oxidation-reduction process]
Show all
 82 aa
9.4 kDa 		No 0
MSRA-005
ENSP00000371930
ENST00000382490
Q9UJ68 [Direct mapping]
Mitochondrial peptide methionine sulfoxide reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006464 [cellular protein modification process]
GO:0006555 [methionine metabolic process]
GO:0006979 [response to oxidative stress]
GO:0008113 [peptide-methionine (S)-S-oxide reductase activity]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030091 [protein repair]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 192 aa
21.5 kDa 		No 0
MSRA-006
ENSP00000429461
ENST00000518255
E5RIA9 [Direct mapping]
Mitochondrial peptide methionine sulfoxide reductase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006979 [response to oxidative stress]
GO:0008113 [peptide-methionine (S)-S-oxide reductase activity]
GO:0015629 [actin cytoskeleton]
GO:0030091 [protein repair]
GO:0055114 [oxidation-reduction process]
Show all
 213 aa
23.6 kDa 		Yes 0
MSRA-008
ENSP00000427725
ENST00000521686
H0YAN3 [Direct mapping]
Mitochondrial peptide methionine sulfoxide reductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006979 [response to oxidative stress]
GO:0008113 [peptide-methionine (S)-S-oxide reductase activity]
GO:0030091 [protein repair]
GO:0055114 [oxidation-reduction process]
Show all
 91 aa
10.5 kDa 		No 0
MSRA-011
ENSP00000436839
ENST00000528246
Q9UJ68 [Direct mapping]
Mitochondrial peptide methionine sulfoxide reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006464 [cellular protein modification process]
GO:0006555 [methionine metabolic process]
GO:0006979 [response to oxidative stress]
GO:0008113 [peptide-methionine (S)-S-oxide reductase activity]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030091 [protein repair]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 169 aa
19 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.