Tissue expression of TSPEAR - Summary - The Human Protein Atlas

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TSPEAR

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TSPEAR
Gene description	Thrombospondin-type laminin G domain and EAR repeats
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enhanced (testis, pituitary gland)
FANTOM5:	Tissue enriched (pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in megakaryocytes of bone marrow, including a secreted positivity in several tissues.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 3 antibodies. HPA052995 , CAB034203 , CAB034204
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION
Gene name	TSPEAR (HGNC Symbol)
Synonyms	C21orf29, DFNB98, MGC11251, TSP-EAR
Description	Thrombospondin-type laminin G domain and EAR repeats (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains a N-terminal thrombospondin-type laminin G domain and several tandem arranged epilepsy-associated repeats (EARs). A mutation in this gene is the cause of autosomal recessive deafness-98. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	44497892 - 44711580
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175894 (version 83.38)
Entrez gene	54084
UniProt	Q8WU66 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WU66
Antibodypedia	TSPEAR antibodies

PROTEIN BROWSER

TSPEAR-001	TSPEAR-002	TSPEAR-201	TSPEAR-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSPEAR-001 ENSP00000321987 ENST00000323084	Q8WU66 [Direct mapping] Thrombospondin-type laminin G domain and EAR repeat-containing protein Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0007605 [sensory perception of sound] GO:0009986 [cell surface] GO:0032420 [stereocilium] Show all	669 aa 74.9 kDa	Yes	0
TSPEAR-002 ENSP00000381012 ENST00000397916	A8MW19 [Direct mapping] Chromosome 21 open reading frame 29, isoform CRA_c; Thrombospondin-type laminin G domain and EAR repeat-containing protein Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		530 aa 59.7 kDa	No	0
TSPEAR-201 ENSP00000478010 ENST00000613245	Q14C60 [Direct mapping] C21orf29 protein; Thrombospondin-type laminin G domain and EAR repeat-containing protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		522 aa 58.9 kDa	Yes	0
TSPEAR-202 ENSP00000482422 ENST00000614657	A0A087WZ72 [Direct mapping] Thrombospondin-type laminin G domain and EAR repeat-containing protein Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		601 aa 67.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.