Fields »
ABOUT
HELP
BLOG
ASCL3

GENERAL INFORMATION

Gene name

 ASCL3

Gene description

 Achaete-scute family bHLH transcription factor 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (salivary gland)
GTEx:Tissue enriched (salivary gland)

Protein evidence

 Evidence at transcript level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA027032
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION

Gene name

 ASCL3 (HGNC Symbol)

Synonyms

 bHLHa42, HASH3, Sgn1

Description

 Achaete-scute family bHLH transcription factor 3 (HGNC Symbol)

Entrez gene summary

 Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 8937579 - 8938211

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000176009 (version 83.38)

Entrez gene

 56676

UniProt

 Q9NQ33 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9NQ33

Antibodypedia

 ASCL3 antibodies

PROTEIN BROWSER
ASCL3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASCL3-001
ENSP00000435770
ENST00000531618
Q9NQ33 [Direct mapping]
Achaete-scute homolog 3
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
Show all
 181 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.