Expression of CRLF3 in cancer - Summary

CANCER ATLAS

Gene description

Cytokine receptor-like factor 3

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Lymphoma

STAINING SUMMARY

HPA007596

GENE INFORMATION
Gene name	CRLF3 (HGNC Symbol)
Synonyms	CREME9, CYTOR4
Description	Cytokine receptor-like factor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	30769388 - 30824776
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176390 (version 83.38)
Entrez gene	51379
UniProt	Q8IUI8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IUI8
Antibodypedia	CRLF3 antibodies

PROTEIN BROWSER

CRLF3-001	CRLF3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRLF3-001 ENSP00000318804 ENST00000324238	Q8IUI8 [Direct mapping] Cytokine receptor-like factor 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0030308 [negative regulation of cell growth] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046427 [positive regulation of JAK-STAT cascade] GO:0071158 [positive regulation of cell cycle arrest] Show all	442 aa 49.8 kDa	No	0
CRLF3-006 ENSP00000463689 ENST00000583527	J3QLS9 [Direct mapping] Cytokine receptor-like factor 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		118 aa 12.7 kDa	No	0