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CRLF3

GENERAL INFORMATION

Gene name

 CRLF3

Gene description

 Cytokine receptor-like factor 3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in subsets of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA007596
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CRLF3 (HGNC Symbol)

Synonyms

 CREME9, CYTOR4

Description

 Cytokine receptor-like factor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 30769388 - 30824776

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176390 (version 83.38)

Entrez gene

 51379

UniProt

 Q8IUI8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IUI8

Antibodypedia

 CRLF3 antibodies

PROTEIN BROWSER
CRLF3-001
CRLF3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRLF3-001
ENSP00000318804
ENST00000324238
Q8IUI8 [Direct mapping]
Cytokine receptor-like factor 3
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0030308 [negative regulation of cell growth]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0071158 [positive regulation of cell cycle arrest]
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 442 aa
49.8 kDa 		No 0
CRLF3-006
ENSP00000463689
ENST00000583527
J3QLS9 [Direct mapping]
Cytokine receptor-like factor 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 118 aa
12.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.