Expression of LPCAT4 in cancer - Summary

CANCER ATLAS

Gene description

Lysophosphatidylcholine acyltransferase 4

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA030719

GENE INFORMATION
Gene name	LPCAT4 (HGNC Symbol)
Synonyms	AGPAT7, AYTL3, FLJ10257, LPAAT-eta, LPEAT2
Description	Lysophosphatidylcholine acyltransferase 4 (HGNC Symbol)
Entrez gene summary	Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
Chromosome	15
Cytoband	q14
Chromosome location (bp)	34358618 - 34367278
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176454 (version 83.38)
Entrez gene	254531
UniProt	Q643R3 (UniProt - Evidence at protein level)
neXtProt	NX_Q643R3
Antibodypedia	LPCAT4 antibodies

PROTEIN BROWSER

LPCAT4-001	LPCAT4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPCAT4-001 ENSP00000317300 ENST00000314891	Q643R3 [Direct mapping] Lysophospholipid acyltransferase LPCAT4 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0036148 [phosphatidylglycerol acyl-chain remodeling] GO:0036150 [phosphatidylserine acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0047166 [1-alkenylglycerophosphoethanolamine O-acyltransferase activity] GO:0047184 [1-acylglycerophosphocholine O-acyltransferase activity] GO:0047192 [1-alkylglycerophosphocholine O-acetyltransferase activity] GO:0071617 [lysophospholipid acyltransferase activity] Show all	524 aa 57.2 kDa	No	2
LPCAT4-201 ENSP00000478003 ENST00000617710	A0A0C4DGT4 [Direct mapping] Lysophospholipid acyltransferase LPCAT4 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016746 [transferase activity, transferring acyl groups] Show all	351 aa 38.2 kDa	No	0