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LPCAT4

GENERAL INFORMATION

Gene name

 LPCAT4

Gene description

 Lysophosphatidylcholine acyltransferase 4

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues, granular expression in some tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA030719
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LPCAT4 (HGNC Symbol)

Synonyms

 AGPAT7, AYTL3, FLJ10257, LPAAT-eta, LPEAT2

Description

 Lysophosphatidylcholine acyltransferase 4 (HGNC Symbol)

Entrez gene summary

 Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]

Chromosome

 15

Cytoband

 q14

Chromosome location (bp)

 34358618 - 34367278

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176454 (version 83.38)

Entrez gene

 254531

UniProt

 Q643R3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q643R3

Antibodypedia

 LPCAT4 antibodies

PROTEIN BROWSER
LPCAT4-001
LPCAT4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LPCAT4-001
ENSP00000317300
ENST00000314891
Q643R3 [Direct mapping]
Lysophospholipid acyltransferase LPCAT4
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0019432 [triglyceride biosynthetic process]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047166 [1-alkenylglycerophosphoethanolamine O-acyltransferase activity]
GO:0047184 [1-acylglycerophosphocholine O-acyltransferase activity]
GO:0047192 [1-alkylglycerophosphocholine O-acetyltransferase activity]
GO:0071617 [lysophospholipid acyltransferase activity]
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 524 aa
57.2 kDa 		No 2
LPCAT4-201
ENSP00000478003
ENST00000617710
A0A0C4DGT4 [Direct mapping]
Lysophospholipid acyltransferase LPCAT4
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
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 351 aa
38.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.