Cell atlas - LMNB2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LMNB2

premium

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane

Human cell
	Nuclear membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	LMNB2
Gene description	Lamin B2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA062477
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane.

Main location

Nuclear membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062477	A-431	Nuclear membrane
	HPA062477	U-2 OS	Nuclear membrane
	HPA062477	U-251 MG	Nuclear membrane

GENE INFORMATION
Gene name	LMNB2 (HGNC Symbol)
Synonyms	LMN2
Description	Lamin B2 (HGNC Symbol)
Entrez gene summary	This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	2427638 - 2456996
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176619 (version 83.38)
Entrez gene	84823
UniProt
neXtProt
Antibodypedia	LMNB2 antibodies

PROTEIN BROWSER

LMNB2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LMNB2-001 ENSP00000327054 ENST00000325327	J9JID7 [Direct mapping] Lamin B2, isoform CRA_a; Lamin-B2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005638 [lamin filament] GO:0005882 [intermediate filament] Show all	620 aa 69.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.