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GRIN1

GENERAL INFORMATION

Gene name

 GRIN1

Gene description

 Glutamate receptor, ionotropic, N-methyl D-aspartate 1

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
RAS pathway related proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebral cortex, cerebellum, caudate, hypothalamus, hippocampus)
FANTOM5:Group enriched (caudate, hippocampus, brain, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 High expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB006831
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, cerebellum, caudate, hypothalamus, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, hippocampus, brain, cerebellum)

GENE INFORMATION

Gene name

 GRIN1 (HGNC Symbol)

Synonyms

 GluN1, NMDAR1

Description

 Glutamate receptor, ionotropic, N-methyl D-aspartate 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 137138390 - 137168762

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176884 (version 83.38)

Entrez gene

 2902

UniProt

 Q05586 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05586

Antibodypedia

 GRIN1 antibodies

PROTEIN BROWSER
GRIN1-002
GRIN1-005
GRIN1-006
GRIN1-007
GRIN1-008
GRIN1-009
GRIN1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRIN1-002
ENSP00000360616
ENST00000371561
Q05586 [Direct mapping]
Glutamate receptor ionotropic, NMDA 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008021 [synaptic vesicle]
GO:0008286 [insulin receptor signaling pathway]
GO:0008542 [visual learning]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016594 [glycine binding]
GO:0016595 [glutamate binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018964 [propylene metabolic process]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042165 [neurotransmitter binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043083 [synaptic cleft]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0055074 [calcium ion homeostasis]
GO:0060076 [excitatory synapse]
GO:0060079 [excitatory postsynaptic potential]
GO:0070588 [calcium ion transmembrane transport]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 938 aa
105.4 kDa 		Yes 3
GRIN1-005
ENSP00000360605
ENST00000371550
Q05586 [Direct mapping]
Glutamate receptor ionotropic, NMDA 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008021 [synaptic vesicle]
GO:0008286 [insulin receptor signaling pathway]
GO:0008542 [visual learning]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016594 [glycine binding]
GO:0016595 [glutamate binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018964 [propylene metabolic process]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042165 [neurotransmitter binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043083 [synaptic cleft]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0055074 [calcium ion homeostasis]
GO:0060076 [excitatory synapse]
GO:0060079 [excitatory postsynaptic potential]
GO:0070588 [calcium ion transmembrane transport]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 901 aa
101.2 kDa 		Yes 3
GRIN1-006
ENSP00000360601
ENST00000371546
Q05586 [Direct mapping]
Glutamate receptor ionotropic, NMDA 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008021 [synaptic vesicle]
GO:0008286 [insulin receptor signaling pathway]
GO:0008542 [visual learning]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016594 [glycine binding]
GO:0016595 [glutamate binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018964 [propylene metabolic process]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042165 [neurotransmitter binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043083 [synaptic cleft]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0055074 [calcium ion homeostasis]
GO:0060076 [excitatory synapse]
GO:0060079 [excitatory postsynaptic potential]
GO:0070588 [calcium ion transmembrane transport]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 959 aa
107.9 kDa 		Yes 3
GRIN1-007
ENSP00000360610
ENST00000371555
Q5VSF9 [Direct mapping]
Glutamate receptor ionotropic, NMDA 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
RAS pathway related proteins
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 922 aa
103.7 kDa 		Yes 3
GRIN1-008
ENSP00000360608
ENST00000371553
Q05586 [Direct mapping]
Glutamate receptor ionotropic, NMDA 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001661 [conditioned taste aversion]
GO:0001964 [startle response]
GO:0001967 [suckling behavior]
GO:0001975 [response to amphetamine]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [receptor binding]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007585 [respiratory gaseous exchange]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007616 [long-term memory]
GO:0008021 [synaptic vesicle]
GO:0008286 [insulin receptor signaling pathway]
GO:0008306 [associative learning]
GO:0008344 [adult locomotory behavior]
GO:0008355 [olfactory learning]
GO:0008542 [visual learning]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010646 [regulation of cell communication]
GO:0010942 [positive regulation of cell death]
GO:0014069 [postsynaptic density]
GO:0014070 [response to organic cyclic compound]
GO:0014075 [response to amine]
GO:0016020 [membrane]
GO:0016594 [glycine binding]
GO:0016595 [glutamate binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018964 [propylene metabolic process]
GO:0019233 [sensory perception of pain]
GO:0019899 [enzyme binding]
GO:0021586 [pons maturation]
GO:0021987 [cerebral cortex development]
GO:0022843 [voltage-gated cation channel activity]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035176 [social behavior]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0035254 [glutamate receptor binding]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042165 [neurotransmitter binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043083 [synaptic cleft]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0043278 [response to morphine]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043576 [regulation of respiratory gaseous exchange]
GO:0044307 [dendritic branch]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048511 [rhythmic process]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0050770 [regulation of axonogenesis]
GO:0050905 [neuromuscular process]
GO:0051262 [protein tetramerization]
GO:0051592 [response to calcium ion]
GO:0051963 [regulation of synapse assembly]
GO:0055074 [calcium ion homeostasis]
GO:0060076 [excitatory synapse]
GO:0060079 [excitatory postsynaptic potential]
GO:0060134 [prepulse inhibition]
GO:0060179 [male mating behavior]
GO:0060992 [response to fungicide]
GO:0070588 [calcium ion transmembrane transport]
GO:0071287 [cellular response to manganese ion]
GO:0097481 [neuronal postsynaptic density]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 943 aa
106 kDa 		Yes 3
GRIN1-009
ENSP00000360614
ENST00000371559
Q05586 [Direct mapping]
Glutamate receptor ionotropic, NMDA 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008021 [synaptic vesicle]
GO:0008286 [insulin receptor signaling pathway]
GO:0008542 [visual learning]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016594 [glycine binding]
GO:0016595 [glutamate binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018964 [propylene metabolic process]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042165 [neurotransmitter binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043083 [synaptic cleft]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0055074 [calcium ion homeostasis]
GO:0060076 [excitatory synapse]
GO:0060079 [excitatory postsynaptic potential]
GO:0070588 [calcium ion transmembrane transport]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 885 aa
99.3 kDa 		Yes 3
GRIN1-010
ENSP00000360615
ENST00000371560
Q05586 [Direct mapping]
Glutamate receptor ionotropic, NMDA 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008021 [synaptic vesicle]
GO:0008286 [insulin receptor signaling pathway]
GO:0008542 [visual learning]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016594 [glycine binding]
GO:0016595 [glutamate binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018964 [propylene metabolic process]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042165 [neurotransmitter binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043083 [synaptic cleft]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0055074 [calcium ion homeostasis]
GO:0060076 [excitatory synapse]
GO:0060079 [excitatory postsynaptic potential]
GO:0070588 [calcium ion transmembrane transport]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 906 aa
101.9 kDa 		Yes 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.