Expression of ANKLE2 in cancer - Summary

CANCER ATLAS

Gene description

Ankyrin repeat and LEM domain containing 2

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003602

GENE INFORMATION
Gene name	ANKLE2 (HGNC Symbol)
Synonyms	KIAA0692, Lem4, LEMD7
Description	Ankyrin repeat and LEM domain containing 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]
Chromosome	12
Cytoband	q24.33
Chromosome location (bp)	132725503 - 132761888
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176915 (version 83.38)
Entrez gene	23141
UniProt	Q86XL3 (UniProt - Evidence at protein level)
neXtProt	NX_Q86XL3
Antibodypedia	ANKLE2 antibodies

PROTEIN BROWSER

ANKLE2-001	ANKLE2-003	ANKLE2-008	ANKLE2-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKLE2-001 ENSP00000350686 ENST00000357997	Q86XL3 [Direct mapping] Ankyrin repeat and LEM domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007067 [mitotic nuclear division] GO:0007084 [mitotic nuclear envelope reassembly] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0016020 [membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034047 [regulation of protein phosphatase type 2A activity] GO:0035307 [positive regulation of protein dephosphorylation] GO:0042326 [negative regulation of phosphorylation] GO:0050790 [regulation of catalytic activity] GO:0051301 [cell division] GO:0051721 [protein phosphatase 2A binding] Show all	938 aa 104.1 kDa	No	1
ANKLE2-003 ENSP00000438551 ENST00000542657	Q86XL3 [Direct mapping] Ankyrin repeat and LEM domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007067 [mitotic nuclear division] GO:0007084 [mitotic nuclear envelope reassembly] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0016020 [membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034047 [regulation of protein phosphatase type 2A activity] GO:0035307 [positive regulation of protein dephosphorylation] GO:0042326 [negative regulation of phosphorylation] GO:0050790 [regulation of catalytic activity] GO:0051301 [cell division] GO:0051721 [protein phosphatase 2A binding] Show all	293 aa 32 kDa	No	0
ANKLE2-008 ENSP00000445760 ENST00000538766	F5H1D4 [Direct mapping] Ankyrin repeat and LEM domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		258 aa 28.4 kDa	No	0
ANKLE2-014 ENSP00000437807 ENST00000542282	Q86XL3 [Direct mapping] Ankyrin repeat and LEM domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007067 [mitotic nuclear division] GO:0007084 [mitotic nuclear envelope reassembly] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0016020 [membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034047 [regulation of protein phosphatase type 2A activity] GO:0035307 [positive regulation of protein dephosphorylation] GO:0042326 [negative regulation of phosphorylation] GO:0050790 [regulation of catalytic activity] GO:0051301 [cell division] GO:0051721 [protein phosphatase 2A binding] Show all	293 aa 32 kDa	No	0