Expression of SIX5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

SIX homeobox 5

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042068

GENE INFORMATION
Gene name	SIX5 (HGNC Symbol)
Synonyms	DMAHP
Description	SIX homeobox 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	45764785 - 45769226
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177045 (version 83.38)
Entrez gene	147912
UniProt	Q8N196 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N196
Antibodypedia	SIX5 antibodies

PROTEIN BROWSER

SIX5-001	SIX5-003	SIX5-004	SIX5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIX5-001 ENSP00000316842 ENST00000317578	Q8N196 [Direct mapping] Homeobox protein SIX5 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002088 [lens development in camera-type eye] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007286 [spermatid development] GO:0008285 [negative regulation of cell proliferation] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1902723 [negative regulation of skeletal muscle satellite cell proliferation] Show all	739 aa 74.6 kDa	No	0
SIX5-003 ENSP00000453239 ENST00000560160	H0YLK1 [Direct mapping] Homeobox protein SIX5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	255 aa 28.3 kDa	No	0
SIX5-004 ENSP00000453189 ENST00000560168	H0YLF6 [Direct mapping] Homeobox protein SIX5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.3 kDa	No	0
SIX5-201 ENSP00000481365 ENST00000622857	A0A087WXX3 [Direct mapping] Homeobox protein SIX5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 15.8 kDa	No	0