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SIX5

GENERAL INFORMATION

Gene name

 SIX5

Gene description

 SIX homeobox 5

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA042068
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SIX5 (HGNC Symbol)

Synonyms

 DMAHP

Description

 SIX homeobox 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 45764785 - 45769226

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177045 (version 83.38)

Entrez gene

 147912

UniProt

 Q8N196 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N196

Antibodypedia

 SIX5 antibodies

PROTEIN BROWSER
SIX5-001
SIX5-003
SIX5-004
SIX5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIX5-001
ENSP00000316842
ENST00000317578
Q8N196 [Direct mapping]
Homeobox protein SIX5
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0002088 [lens development in camera-type eye]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007286 [spermatid development]
GO:0008285 [negative regulation of cell proliferation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:1902723 [negative regulation of skeletal muscle satellite cell proliferation]
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 739 aa
74.6 kDa 		No 0
SIX5-003
ENSP00000453239
ENST00000560160
H0YLK1 [Direct mapping]
Homeobox protein SIX5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
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 255 aa
28.3 kDa 		No 0
SIX5-004
ENSP00000453189
ENST00000560168
H0YLF6 [Direct mapping]
Homeobox protein SIX5
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 69 aa
7.3 kDa 		No 0
SIX5-201
ENSP00000481365
ENST00000622857
A0A087WXX3 [Direct mapping]
Homeobox protein SIX5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 158 aa
15.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.