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EPS8L2

GENERAL INFORMATION

Gene name

 EPS8L2

Gene description

 EPS8-like 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA041143
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

 EPS8L2 (HGNC Symbol)

Synonyms

 FLJ21935, FLJ22171, MGC3088

Description

 EPS8-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 694438 - 727727

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177106 (version 83.38)

Entrez gene

 64787

UniProt

 Q9H6S3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H6S3

Antibodypedia

 EPS8L2 antibodies

PROTEIN BROWSER
«
EPS8L2-001
EPS8L2-002
EPS8L2-003
EPS8L2-006
EPS8L2-008
EPS8L2-009
EPS8L2-016
EPS8L2-026
EPS8L2-027
EPS8L2-201
EPS8L2-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPS8L2-001
ENSP00000320828
ENST00000318562
Q9H6S3 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1900029 [positive regulation of ruffle assembly]
Show all
 715 aa
80.6 kDa 		No 0
EPS8L2-002
ENSP00000436035
ENST00000530636
Q9H6S3 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1900029 [positive regulation of ruffle assembly]
Show all
 715 aa
80.6 kDa 		No 0
EPS8L2-003
ENSP00000435585
ENST00000533256
Q9H6S3 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1900029 [positive regulation of ruffle assembly]
Show all
 715 aa
80.6 kDa 		No 0
EPS8L2-006
ENSP00000436230
ENST00000526198
Q9H6S3 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1900029 [positive regulation of ruffle assembly]
Show all
 731 aa
82.3 kDa 		No 0
EPS8L2-008
ENSP00000435128
ENST00000524763
E9PLH1 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 105 aa
11.7 kDa 		No 0
EPS8L2-009
ENSP00000437085
ENST00000527199
E9PNY4 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 25 aa
2.3 kDa 		No 0
EPS8L2-016
ENSP00000433223
ENST00000533500
E9PLN2 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 83 aa
9 kDa 		No 0
EPS8L2-026
ENSP00000432765
ENST00000531348
E9PNT0 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 95 aa
10.5 kDa 		No 0
EPS8L2-027
ENSP00000432923
ENST00000534755
E9PN68 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 79 aa
8.6 kDa 		No 0
EPS8L2-201
ENSP00000480704
ENST00000610855
A0A087WX39 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 232 aa
25.4 kDa 		No 0
EPS8L2-202
ENSP00000480201
ENST00000614442
Q9H6S3 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1900029 [positive regulation of ruffle assembly]
Show all
 731 aa
82.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.