Cell atlas - TALDO1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TALDO1
Gene description	Transaldolase 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Cytosol (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA040373 , HPA048089
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (validated)

Additional location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA040373	A-431	No staining
HPA040373	U-2 OS	Nucleoplasm	Intensity
HPA040373	U-2 OS	Cytosol
HPA048089	A-431	Nucleus
HPA048089	A-431	Cytosol
HPA048089	A549	Nucleoplasm	Intensity
HPA048089	A549	Cytosol
HPA048089	U-2 OS	Nucleus	Intensity

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000025503 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA048089	NIH 3T3	No staining

GENE INFORMATION
Gene name	TALDO1
Synonyms
Description	Transaldolase 1 (HGNC Symbol)
Entrez gene summary	Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	747329 - 765024
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177156 (version 83.38)
Entrez gene	6888
UniProt	P37837 (UniProt - Evidence at protein level)
neXtProt	NX_P37837
Antibodypedia	TALDO1 antibodies

PROTEIN BROWSER

TALDO1-001	TALDO1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TALDO1-001 ENSP00000321259 ENST00000319006	P37837 [Direct mapping] Transaldolase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004801 [sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005999 [xylulose biosynthetic process] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006098 [pentose-phosphate shunt] GO:0006112 [energy reserve metabolic process] GO:0009052 [pentose-phosphate shunt, non-oxidative branch] GO:0019682 [glyceraldehyde-3-phosphate metabolic process] GO:0030246 [carbohydrate binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0048029 [monosaccharide binding] GO:0070062 [extracellular exosome] Show all	337 aa 37.5 kDa	No	0
TALDO1-010 ENSP00000437098 ENST00000528097	F2Z393 [Direct mapping] Transaldolase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004801 [sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006098 [pentose-phosphate shunt] Show all	318 aa 35.3 kDa	No	0