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FZD8

GENERAL INFORMATION

Gene name

 FZD8

Gene description

 Frizzled class receptor 8

Protein class

 G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA045025
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FZD8

Synonyms

Description

 Frizzled class receptor 8 (HGNC Symbol)

Entrez gene summary

 This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p11.21

Chromosome location (bp)

 35638249 - 35642278

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177283 (version 83.38)

Entrez gene

 8325

UniProt

 Q9H461 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H461

Antibodypedia

 FZD8 antibodies

PROTEIN BROWSER
FZD8-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FZD8-001
ENSP00000363826
ENST00000374694
Q9H461 [Direct mapping]
Frizzled-8
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001525 [angiogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016055 [Wnt signaling pathway]
GO:0017147 [Wnt-protein binding]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033077 [T cell differentiation in thymus]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042813 [Wnt-activated receptor activity]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060070 [canonical Wnt signaling pathway]
GO:1990851 [Frizzled-LRP5/6 complex]
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 694 aa
73.3 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.