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GJD4

GENERAL INFORMATION

Gene name

 GJD4

Gene description

 Gap junction protein, delta 4, 40.1kDa

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Not detected
FANTOM5:Not detected

Protein evidence

 Evidence at transcript level

Protein expression

 Nuclear membrane positivity.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA038266
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 GJD4 (HGNC Symbol)

Synonyms

 CX40.1, FLJ90023

Description

 Gap junction protein, delta 4, 40.1kDa (HGNC Symbol)

Entrez gene summary

 Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 p11.21

Chromosome location (bp)

 35605410 - 35608935

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000177291 (version 83.38)

Entrez gene

 219770

UniProt

 Q96KN9 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96KN9

Antibodypedia

 GJD4 antibodies

PROTEIN BROWSER
GJD4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GJD4-001
ENSP00000315070
ENST00000321660
Q96KN9 [Direct mapping]
Gap junction delta-4 protein
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
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GO:0005886 [plasma membrane]
GO:0005922 [connexon complex]
GO:0007154 [cell communication]
GO:0014717 [regulation of satellite cell activation involved in skeletal muscle regeneration]
GO:0016021 [integral component of membrane]
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 370 aa
40.1 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.