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PAWR

CANCER ATLAS

Gene description

 PRKC, apoptosis, WT1, regulator

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA012640
CAB020779

GENE INFORMATION

Gene name

 PAWR (HGNC Symbol)

Synonyms

 par-4, PAR4

Description

 PRKC, apoptosis, WT1, regulator (HGNC Symbol)

Entrez gene summary

 The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q21.2

Chromosome location (bp)

 79574979 - 79691097

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177425 (version 83.38)

Entrez gene

 5074

UniProt

 Q96IZ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96IZ0

Antibodypedia

 PAWR antibodies

PROTEIN BROWSER
PAWR-001
PAWR-002
PAWR-006
PAWR-008
PAWR-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAWR-001
ENSP00000328088
ENST00000328827
Q96IZ0 [Direct mapping]
PRKC apoptosis WT1 regulator protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008157 [protein phosphatase 1 binding]
GO:0009611 [response to wounding]
GO:0010040 [response to iron(II) ion]
GO:0015629 [actin cytoskeleton]
GO:0019899 [enzyme binding]
GO:0030424 [axon]
GO:0030889 [negative regulation of B cell proliferation]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0042094 [interleukin-2 biosynthetic process]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042986 [positive regulation of amyloid precursor protein biosynthetic process]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045760 [positive regulation of action potential]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0051017 [actin filament bundle assembly]
GO:0060450 [positive regulation of hindgut contraction]
GO:0071306 [cellular response to vitamin E]
GO:0071347 [cellular response to interleukin-1]
GO:0071372 [cellular response to follicle-stimulating hormone stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090281 [negative regulation of calcium ion import]
GO:0097190 [apoptotic signaling pathway]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:1901082 [positive regulation of relaxation of smooth muscle]
GO:1903238 [positive regulation of leukocyte tethering or rolling]
GO:1904457 [positive regulation of neuronal action potential]
GO:1990035 [calcium ion import into cell]
GO:2000391 [positive regulation of neutrophil extravasation]
Show all
 340 aa
36.6 kDa 		No 0
PAWR-002
ENSP00000447454
ENST00000548426
F8W1M8 [Direct mapping]
PRKC apoptosis WT1 regulator protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
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 76 aa
7.4 kDa 		No 0
PAWR-006
ENSP00000448317
ENST00000551712
H0YI16 [Direct mapping]
PRKC apoptosis WT1 regulator protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
Show all
 194 aa
20.1 kDa 		No 0
PAWR-008
ENSP00000449928
ENST00000552637
A0A0B4J260 [Direct mapping]
PRKC apoptosis WT1 regulator protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
6.3 kDa 		No 0
PAWR-009
ENSP00000447507
ENST00000550603
H0YHP5 [Direct mapping]
PRKC apoptosis WT1 regulator protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
Show all
 72 aa
8.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.